Omalizumab is an FDA approved treatment option for patients over 12 years of age with severe allergic asthma and patients over 12 years of age with chronic urticaria or hives . It is an injection that is given in our clinic every 2-4 weeks. Due to the possibility of a severe allergic reaction, all doses are given in our clinic. The first three doses require a 2-hour wait and all other doses require a 30-minute wait. Although a severe allergic reaction is rare, you are required to have an epinephrine auto-injector in case of a severe allergic reaction to the injection.