Omalizumab is an FDA approved treatment option for patients over 12 years of age with severe allergic asthma and patients over 12 years of age with chronic urticaria or hives. It is an injection that is given in our clinic every 2-4 weeks. Due to the possibility of a severe allergic reaction, all doses are given in our clinic. The first three doses require a 2-hour wait and all other doses require a 30-minute wait. Although a severe allergic reaction is rare, you are required to have an epinephrine auto-injector in case of a severe allergic reaction to the injection.